Heitor S. F. de Souza
Professor Titular da Faculdade de Medicina da Universidade Federal do Rio de Janeiro
Pesquisador colaborador do Instituto D’Or de Pesquisa e Ensino
Doutorado pela Universidade Federal do Rio de Janeiro
Pós-doutorado pela Cleveland Clinic
Membro Titular da Federação Brasileira de Gastroenterologia e do Grupo de Estudo de Doenças Inflamatórias Intestinais do Brasil (GEDIIB)
Fellow da Associação Americana de Gastroenterologia (AGA)
Vice-presidente da Associação de Gastroenterologia do Rio de Janeiro (2023-24)
Coordenador do Programa de Pós-graduação em Clínica Médica da Universidade Federal do Rio de Janeiro
ARTIGO
Geosocial Features and Loss of Biodiversity Underlie Variable Rates of Inflammatory Bowel Disease in a Large Developing Country: A Population-Based Study
The analysis of a large population of inflammatory bowel disease (IBD) patients in a developing country reveals that the rising pre
ARTIGO
The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?
The overall burden of cancer is rapidly increasing worldwide, reflecting not only population growth and aging, but also the prevalence and spread of risk factors. Gastrointestinal (GI) cancers, including stomach, liver, esophageal, pancreatic, and colorectal cancers, represent more than a quarter of all cancers. While smoking and alcohol use are the risk factors most commonly associated with cancer development, a growing consensus also includes dietary habits as relevant risk factors for GI cancers. Current evidence suggests that socioeconomic development results in several lifestyle modifications, including shifts in dietary habits from local traditional diets to less-healthy Western diets. Moreover, recent data indicate that increased production and consumption of processed foods underlies the current pandemics of obesity and related metabolic disorders, which are directly or indirectly associated with the emergence of various chronic noncommunicable conditions and GI cancers. However, environmental changes are not restricted to dietary patterns, and unhealthy behavioral features should be analyzed with a holistic view of lifestyle. In this review, we discussed the epidemiological aspects, gut dysbiosis, and cellular and molecular characteristics of GI cancers and explored the impact of unhealthy behaviors, diet, and physical activity on developing GI cancers in the context of progressive societal changes.